Characteristics of serum free fatty acid and high-sensitivity C-reactive protein in patients with type 2 diabetes mellitus and metabolic syndrome
10.3760/cma.j.issn.1674-635X.2015.06.005
- VernacularTitle:2型糖尿病并发代谢综合征患者血清游离脂肪酸与高敏C反应蛋白特征
- Author:
Dajun LOU
;
Qiqian ZHU
;
Weikun GONG
;
Fei YE
;
Haiyan DONG
;
Dihua HUANG
;
Xuwei SI
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome;
Type 2 diabetes mellitus;
Serum free fatty acid;
High-sensitivity Creactive protein
- From:
Chinese Journal of Clinical Nutrition
2015;23(6):351-355
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate characteristics of free fatty acid (FFA) and high-sensitivity Creactive protein (hs-CRP) in patients with type 2 diabetes mellitus and metabolic syndrome (MS) compared to those with type 2 diabetes mellitus without MS.Methods Totally 120 patients with type 2 diabetes mellitus who received blood glucose control in Shaoxing People's Hospital from January to June 2013 were recruited and divided into MS group (n =56) and non-MS group (n =64).The serum FFA profile of the patients was measured by enzymatic assay, and the serum hs-CRP level measured by particle-enhanced immuno-precipitation assay.Results The level of FFA was higher in the MS group than that in the non-MS group [(0.60 ±0.25) mmoL/L vs.(0.45 ±0.21) mmol/L, P =0.033].The level of hs-CRP was higher in the MS group than that in the non-MS group [5.29 (4.69-5.82) mg/L vs.0.73 (0.42-1.26) mg/L, P =0.000].The level of hs-CRP was higher in the patients with central obesity than that in those without central obesity [4.34 (0.91-5.46) mg/L vs.1.80 (0.82-3.27) mg/L, P=0.014], also higher in hypertensive patients than in non-hypertensive patients [5.21 (3.18-5.96) mg/L vs.2.93 (0.89-4.98) mg/L, P =0.012].Conclusions Serum FFA and hs-CRP concentrations may be significantly higher in type 2 diabetes mellitus patients with MS.The increased levels of FFA and hs-CRP may play an important role in the pathogenesis of type 2 diabetes mellitus and MS.
