Clinical Investigation for Blood Levels of Cystetine C and Superoxide Dismutase in Patients With Obstructive Sleep Apnea Syndrome Related Hypertension
10.3969/j.issn.1000-3614.2016.05.011
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征相关性高血压患者血清胱抑素C和超氧化物歧化酶水平的变化
- Author:
Tingting HOU
;
Chuan ZHOU
;
Ping XIE
;
Jianjun DENG
;
Yuping XIE
;
Zhongwei LI
;
Peng SU
;
Wenjing ZHANG
;
Qinli HE
- Publication Type:Journal Article
- Keywords:
Hypertension;
Superoxide dismutase;
Obstructive sleep apnea syndrome;
Cystatine C
- From:
Chinese Circulation Journal
2016;31(5):463-466
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe blood levels of cystetine C (Cys C) and superoxide dismutase (SOD) in patients with obstructive sleep apnea syndromes (OSAS) related hypertension (HP). Methods: A total of 102 HP patients received polysomgography (PSG) in our hospital from 2013-01 to 2013-12 were studied. According to apnea hypopnea index (AHI), the patients were divided into 2 groups: OSAS with HP (OH) group, n=55 patients with AHI≥5 and HP group,n=47 patients with AHI<5; in addition, there was a Control group,n=45 normal subjects with PSG examination at the same period. The general conditions, biochemical and sleep parameters were studied, the differences among 3 groups were analyzed by SPSS 17.0 software. Results: In OH group, HP group and Control group, blood levels of Cys C were (1.06 ± 0.27) mg/L, (0.91 ± 0.19) mg/L and (0.79 ± 0.32) mg/L respectively; SOD were (127.63 ± 63.19) U/mL, (149.14 ± 60.12) U/mL and (181.54 ± 59.37) U/mL respectively, allP<0.05. Based on clinical conditions, OH group was further divided into Mild, Moderate and Severe sub-groups, blood levels of Cys C and SOD were similar among different sub-groups,P>0.05. Conclusion: Blood levels of Cys C in OH and HP groups were higher than Control group, Cys C in OH group was higher than HP group; SOD levels in OH and HP groups were lower than Control group, SOD in OH group was lower than HP group. The relationships between Cys C, SOD and OH severity were unclear.
