Epidemiology and characteristics of antibacterial resistance in China
10.3760/cma.j.issn.1674-2397.2016.02.005
- VernacularTitle:我国细菌耐药现状与特征
- Author:
Jing ZHANG
;
Wei YU
;
Lina ZHAO
;
Yonghong XIAO
- Publication Type:Journal Article
- Keywords:
Methicillin-resistant Staphylococcus aureus;
Streptococcus pneumonia;
Enterococcus;
Carbapenem-resistant Enterobacteriaceae;
Pseudomonas aeruginosa;
Acinetobacter;
Epidemiology;
Molecular characteristics
- From:
Chinese Journal of Clinical Infectious Diseases
2016;9(2):118-128
- CountryChina
- Language:Chinese
-
Abstract:
Currently, bacterial resistance situation in health care settings is very serious in China, and the prevalence of a variety of common multidrug-resistant bacteria and pan-resistant bacteria are relatively high. Drug-resistant bacteria in Gram-positive bacteria are mainly methicillin resistant Staphylococcus aureus ( MRSA ) and macrolide-resistant Streptococcus, while glycopeptide-resistant enterococci are still at a low level.The clonal distribution of MRSA and mechanisms of Streptococcus resistance in China are different from those in European and American countries.Cephalosporins and quinolones resistance are the marked characteristic of Enterobacteriaceae with a high occurrence over 60%. Carbapenem-resistant Klebsiella pneumoniae shows a rapid upward trend, and producing KPC-2 type carbapenemases is the main mechanism of its resistance.Resistance in Pseudomonas aeruginosa is relatively stable, with resistant rates ranging from 20%to 30%.Multi-drug resistant Acinetobacter baumannii is a big problem in clinic.More than 50% Acinetobacter baumannii strains are resistant to carbapenems and cephalosporins, and tigecycline-resistant Acinetobacter baumannii is increasing.This paper systematically reviews the status and characteristics of bacterial resistance in last five years with referring to the surveillance data of antimicrobial resistance and the findings of related mechanisms.
