Advances in the Modulation of Quercetin on Drug Metabolizing Enzymes
- VernacularTitle:槲皮素对药物代谢酶调控作用的研究进展
- Author:
Tingyu YANG
;
Yani LIU
;
Shaojun SHI
- Publication Type:Journal Article
- Keywords:
Quercetin;
Drug-metabolizing enzymes;
Modulation;
In vitro;
In vivo
- From:
China Pharmacist
2016;19(3):555-559
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To summarize the recent research progress in the influence of quercetin on drug metabolizing enzymes. Methods:By referring to the relevant literatures at home and abroad in recent years, the paper summarized, analyzed and concluded the the influence of quercetin on drug metabolizing enzymes. Results: Quercetin could modulate the phase Ⅰmetabolic enzyme cyto-chrome P450 ( CYP) and the phase Ⅱ metabolic enzymes uridine diphosphate - glucuronosyltransferase enzyme ( UGTs) , sulfotrans-ferase ( SULTs) and glutathione S-transferase ( GSTs) to influence the in vitro and in vivo metabolism of a lot of drugs. Meanwhile, the modulation of quercetin on the metabolic enzymes demanded the participation of various nuclear receptors. Conclusion:Quercetin shows the inhibitory or inducing effect on a variety of drug-metabolizing enzymes, therefore, it can interact with other drugs.
