Application and biocompatibility of a new absorbable magnesium alloy stent in blood vessels
10.3969/j.issn.2095-4344.2016.08.015
- VernacularTitle:新型可吸收镁合金支架在血管内应用及生物相容性
- Author:
Hui ZHAO
;
Min LEI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(8):1165-1170
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: In vivo animal experiments have found that magnesium al oy stents can be completely degraded in a slow, orderly and non-toxic manner fol owing the vascular remodeling. OBJECTIVE: To investigate the applied effect and biocompatibility of a new type of magnesium al oy stent in blood vessels. METHODS: Forty-two crossbreed dogs were implanted with absorbable magnesium al oy stents via the coronary artery or left femoral artery. At days 1, 3, 5 and weeks 1, 2, 3, 4 after implantation, coronary or femoral artery angiography, inflammatory factor detection and morphological analysis targeting intimal hyperplasia were performed. RESULTS AND CONCLUSION: At 1 day after implantation, the stents had the complete shape and were ful y extended; at 3 days after implantation, the stents were degraded partial y; at 1 week after implantation, the stents were degraded completely. Within 1-3 weeks after implantation, the levels of tumor necrosis factor α, interleukin-6 and interleukin-8 continued to decrease. At 2 and 3 weeks after implantation, the target vessels presented with mild intimal hyperplasia. As time went on, the hyperplasia area increased gradual y, and the percentage of intimal hyperplasia increased gradual y. Blood magnesium concentration remained unchanged before and after stent implantation. The results show that the new absorbable magnesium al oy stent can be completely degraded within 1 week after stent implantation and has good biocompatibility.
