Association between homocystine and C677T polymorphism with gestational diabetes mellitus

VernacularTitle:同型半胱氨酸及 C677T 基因多态性与妊娠期糖尿病关系分析
Author: Lizi CHENG ; Donge WANG ; Guicheng YE ; Chunlei YUAN ; Jianming PENG
Publication Type:Journal Article
Keywords: homocystine; methylenetetra hydrofolate reductase; polymorphism; gestational diabetes mellitus
From: International Journal of Laboratory Medicine 2016;37(6):736-737
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between homocystine (Hcy) ,methylenetetra hydrofolate reductase(M T H-FR) C677T and gestational diabetes mellitus (GDM ) .Methods A total of 91 GDM cases(GDM group) and 123 cases with normal pregnancy(control group) were detected for the C677T polymorphism of M T HFR and serum levels of Hcy and glucose .Results Serum Hcy level in GDM group was remarkable higher than that of control group (P< 0 .05) .Hcy level was positively correlated with fasting plasma glucose ( P < 0 .05) .The genotype frequencies (CC ,CT ,TT ) of M T HFR C677T in GDM group and control group were with significantly difference(P< 0 .05) .Hcy was significantly higher in women with C677T TT genotype than those with CC genotype(P< 0 .05) .Conclusion Hcy could be related to GDM .The mutation of M T HFR might affect serum Hcy level , and be involved in the occurrence and development of GDM .