Research advance of the timing of renal replacement therapy among people with acute kidney injury

VernacularTitle:急性肾损伤患者肾脏替代治疗时机的研究进展
Author: Dongchen GUO ; Ang LI ; Meili DUAN
Publication Type:Journal Article
Keywords: Acute kidney injury; Renal replacement therapy; Therapy timing
From: Chinese Critical Care Medicine 2016;28(3):285-288
CountryChina
Language:Chinese
Abstract: Acute kidney injury (AKI) is one of the most common serious complications in critically ill patients, and it is an independent risk factor for death. In recent years, renal replacement therapy (RRT) has become one of the routine treatments for AKI patients, however there is no accepted consensus on the optimal timing of RRT over the world. This paper reviewed the clinical studies carried out by researchers in the field of critical care and nephrology, thereby summarized and analyzed the related parameters of the optimal time to carry out, with the exception of previously acknowledged classic RRT indications such as hyperkalemia, severe metabolic acidosis, volume overload and so on. The feasible parameters such as serum creatinine (SCr), blood urea nitrogen (BUN), urine volume, the time admitted in the intensive care unit (ICU) and several standards distinguished AKI stages are discussed in order to find out the cutoff points of those parameters which were best for the patients' outcome, and to provide guidance of decision making for the optimal timing of RRT for AKI patients.