Traditional and novel reference index for the withdrawal of renal replacement therapy in patients with acute kidney injury

VernacularTitle:急性肾损伤患者停止肾脏替代治疗的参考指标：传统与新兴
Author: Tingting YANG ; Mei HAN ; Baihai SU
Publication Type:Journal Article
Keywords: Acute kidney injury; Biomarker; Renal replacement therapy; Reference index of withdrawing renal replacement therapy
From: Chinese Critical Care Medicine 2016;28(3):281-284
CountryChina
Language:Chinese
Abstract: Acute kidney injury (AKI) is a serious clinical problem with high morbidity and mortality. Renal replacement therapy (RRT) is an important tool for treating patients with AKI. The 2011 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for AKI points out that RRT should be discontinued when renal function has recovered enough to meet the body needs or when RRT is no longer consistent with treatment goals. However, the specific reference index of weaning RRT is unclear. The guiding roles of traditional indicators such as urine output (> 400 mL/24 h), serum creatinine (SCr, decreasing trend), creatinine clearance (CCr, > 20 mL/min), and novel biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), hepatocyte growth factor (HGF), interleukins (IL-6, IL-10), kidney injury molecule-1 (KIM-1), kynurenic acid, etc. for discontinuation of RRT in AKI patients were reviewed. Particularly, the importance of biomarkers for this purpose was highlighted.