Research progress of CHD1L′s related molecular mechanism on carcinoma
10.16571/j.cnki.1008-8199.2016.04.023
- VernacularTitle:CHD1L在癌症中相关分子机制的研究进展
- Author:
Shimiao LI
;
Jingwen HUA
;
Changwen HUANG
- Publication Type:Journal Article
- Keywords:
CHD1L;
Cancer;
Molecular mechanism
- From:
Journal of Medical Postgraduates
2016;29(4):445-448
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract ] CHD1L is a newly identified oncogene located at Chr 1q21,its oncogenic role in tumorigenesis is through unleashed cell proliferation, G1/S transition, inhibition of apoptosis and Chromatin instability .It is an independent biomarker that can affect tumour′s process, prognosis and survival rate.The underlying mechanisms of CHD1L activation may disrupt the cell death program via binding the apoptotic protein Nur77 or exterting relevant function by mediate CHD 1L′s target genes (ARHGEF9, TCTP, SPOCK1, and NTKL) .This paper mainly introduces its oncogenic role and research progress of related molecular mechanism .
