The study of visinin-like protein-1 concentration in blood on the mild cognitive impairment and Alzheimer disease
- VernacularTitle:轻度认知障碍和阿尔茨海默病患者血液中视锥样蛋白-1的研究
- Author:
Yaping CHEN
;
Ping LIU
;
Wenli HAO
;
Yongcheng XU
;
Xiaohong LI
;
Xiangzhi ZHANG
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Cognitive impairment;
Visinin-like protein-1;
Early diagnosis
- From:
Chinese Journal of Postgraduates of Medicine
2015;38(z1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the visinin-like protein-1 (VILIP-1) levels in the blood in the Alzheimer disease (AD) and mild cognitive impairment (MCI) due to AD patients,and also to explore its feasibility as a biomarker for the early diagnosis of AD and for the detection of progression of AD.Methods Fifty-eighty participants were included:20 cases for AD group,19 cases for MCI due to AD group,19 cases for normal control group.The level of VILIP-1 was tested by the ELISA method.Results The level of VILIP-1 in AD group was significantly higher than that in normal control group and MCI due to AD group:(9.0 ± 2.9) ng/L vs.(3.3 ± 1.7) and (6.5 ± 3.1) ng/L,and that in MCI due to AD group was significantly higher than that in normal group,there were statistical differences (P ＜ 0.01).The MMSE score in AD group was significantly lower than that in normal group and MCI due to AD group:(15 ± 3) scores vs.(27 ± 2) and (23 ± 2) scores,and that in MCI due to AD group was significantly lower than that in normal group,there were statistical differences (P ＜ 0.01).The level of VILIP-1 was negatively correlated with MMSE score (r =0.463,P ＜ 0.01),but positively correlated with age (r =0.417,P =0.01).Conclusions With the progression of the disease,the cognitive impairment of the AD patient is decreasing.VILIP-1 increased in the blood of the patients of AD and MCI due to AD.It means that the blood VILIP-1 could be a new and potential biomarker for the early diagnosis of AD,and it may be clinical useful for the early diagnosis and effective detection of AD to some extent.
