Role of FoxO3a transcription factor in oxidative stress
10.16571/j.cnki.1008-8199.2016.03.023
- VernacularTitle:FoxO3a转录因子与机体氧化应激损伤的研究进展
- Author:
Yanan ZHANG
;
Baomin CHEN
;
Yang GAO
;
Runping LI
- Publication Type:Journal Article
- Keywords:
FoxO3a;
Oxidative stress;
Signal pathway;
Related diseases
- From:
Journal of Medical Postgraduates
2016;29(3):327-331
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress is an important factor that can cause aging body, tissue damage and diseases.FoxO3a transcription factor is critical for the regulation of oxidative stress.Recently, there are some reports on the quite complex role of FoxO3a in regulating oxidative stress.Not only can it promote the survival of cells, but also induce cell apoptosis at some oxidative stress conditions.In this paper, the role of FoxO3a in oxidative stress, the possible signal pathway and the potential effect of target FoxO3a for oxidative stress diseases treatment are reviewed.
