The research progress of protein lysine succinylation
10.16571/j.cnki.1008-8199.2016.03.024
- VernacularTitle:蛋白质赖氨酸琥珀酰化修饰研究进展
- Author:
Jiajia SHEN
;
Hao WEN
- Publication Type:Journal Article
- Keywords:
Protein succinylation;
Metabolism;
Mass spectrum;
Inflammation
- From:
Journal of Medical Postgraduates
2016;29(3):332-336
- CountryChina
- Language:Chinese
-
Abstract:
Recently the lysine succinylation was discovered in vivo, and it was demonstrated to be widely involved in cell dif-ferentiation, cell metabolism and other important physiological activities.Lysine succinylation has become the forefront of life science research.Scientists have provided a lot of evidences that proteins in prokaryotes and eukaryotes are widely succinylated, without which the central metabolism and intermediary metabolism of many metabolic enzymes are disrupted.To better understand the importance of Succinylation in vivo, protein-succinyl modification of the current research and the latest developments are reviewed, which summarize succinylated protein lysine sites in the center of important physiological metabolic pathways, diseases and other pathological conditions.
