Relationship between C-reactive protein and postoperative cognitive function of female patients who undergoing CPB (cardiopulmonary bypass) cardiac surgery
10.3760/cma.j.issn.1008-1372.2015.12.020
- VernacularTitle:CRP与心脏手术女性患者术后认知功能的关系
- Author:
Huajuan LEI
;
Dequan CAO
- Publication Type:Journal Article
- Keywords:
C-reactive protein/ME;
Cardiac surgical procedures;
Cognition
- From:
Journal of Chinese Physician
2015;17(12):1839-1841
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between C-reactive protein (CRP) and postoperative cognitive function of female patients underwent cardiopulmonary bypass (CPB) cardiac surgery.Methods Sixty female patients were scheduled for CPB surgery from January 2012 to May 2013,aged form 35 to 60 years,mean aged (47.5 ± 12.5) years,and in state of ASAⅡ ～ Ⅲ.All patients had general anesthesia and CPB cardiac surgery.Blood samples were taken from peripheral vein before induction and 6 days after surgery.The neuropsychology assessment was measured with Wechsler Adult Intelligence Scale RC 2 + 1 (WAIS-RC) and digital span the first day preoperative,the 7th day,and the first month postoperative.The postoperative cognitive dysfunction (POCD) was judged with Newman style.Results (1) The rate of POCD of the 7th day and first month postoperatively was 50％ and 25％,respectively.(2) The Pearsong correlation showed negative correlation between CRP preoperative at the 6th day and the 7th day,and the first month postoperative WAIS-RC score(P ＜ 0.05).(3) The Pearson's figure showed negative correlation between CRP at the 6th day postoperative with digital span (P ＜ 0.05).Conclusions The ratio of POCD after CPB surgery was higher.It is instructively significant to monitor the variations of concentration of serum CRP for the selection of cognitive impairment in patients with cardiac-pulmonary bypass surgery.
