TIGAR promotes proliferation and invasiveness of lung cancer cells
10.3969/j.issn.1673-4130.2016.06.014
- VernacularTitle:T IGAR 调节肺癌细胞的增殖和侵袭能力研究
- Author:
Ming ZHAO
;
Jing FENG
;
Yong LIU
;
Linglin YANG
- Publication Type:Journal Article
- Keywords:
TIGAR;
A549;
proliferation;
migration;
invasion
- From:
International Journal of Laboratory Medicine
2016;37(6):754-755
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of P53 target gene TIGAR on proliferation ,migration and invasion of lung cancer cells . Methods siRNA was introduced to knock down TIGAR in A 549 cells .Proliferation was detected by CCK-8 .The ability of migra-tion and invasion was measured by and ,respectively .was used to evaluate the expression levels of related proteins .Results Knock-down of TIGAR reduced the proliferation rate (P< 0 .05) ,inhibited the ability of migration and invasion ,decreased expression levels of MMP-2 and MM P-9 .Conclusion TIGAR promotes proliferation ,migration and invasiveness of lung cancer cells .
