Association between serum cystatin C and carotid intima -media thickness in patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1008-6706.2016.03.007
- VernacularTitle:2型糖尿病患者血清胱抑素C水平与颈动脉内膜中层厚度的关系
- Author:
Dengpan LIANG
;
Xiuping HUANG
;
Shuxia YANG
;
Jing LUO
- Publication Type:Journal Article
- Keywords:
Diabetic mellitus,type 2;
Cystatin C;
Carotid arteries
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(3):346-348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between serum cystatin C and carotid atherosclerosis in patients with type 2 diabetes mellitus.Methods A total of 318 patients with type 2 diabetes mellitus were enrolled in this study.According to the results of carotid color Doppler ultrasound in the patients were randomly divided into two groups:CIMT abnormal group (CIMT was equal to or larger than 0.9 mm,with or without associated with carotid artery plaque formation)CIMT and normal group (CIMT <0.9 mm,and it was not associated with carotid artery atherosclerotic plaque formation.Differences in serum cystatin C,serum lipid and lipoprotein,fasting plasma glucose and other biochemical markers between the two groups were analyzed by using Student's t test.The correlated factors of the carotid thickness and plaque appearance were analyzed by Logistic regression analysis.Results The serum cystatin C levels of the CIMT abnormal group were higher than the normal CIMT group[(1.24 ±0.22)mg/L vs.(1.05 ±0.41)mg/L, t =4.949,P <0.001).Multivariate logistic regression analysis showed adjusted for gender,age and other factors,ser-um cystatin C was independently associated factor of CIMT (OR =2.563,95% CI:1.026 ~6.403,P =0.044). Conclusion Our data suggest that serum cystatin C is significantly associated with carotid atherosclerosis.
