The influences of DAO and SNGF in the treatment of hypothermia for neonates after birth asphyxia
10.3760/cma.j.issn.1008-6706.2016.03.018
- VernacularTitle:亚低温治疗对缺血缺氧患儿血清二胺氧化酶水平及胃肠功能评分的影响
- Author:
Aimin YAO
;
Jianling LI
;
Lijuan XIA
;
Liang YAO
;
Yeqing WANG
;
Hongjing YANG
- Publication Type:Journal Article
- Keywords:
Hypothermia,Induced;
Diamine oxidase;
Neonates;
Asphyxia
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(3):387-390
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of diamine oxidase (DAO)levels in neonates with hypoxic -is-chemic encephalopathy (HIE)treated with selective brain hypothermi,also to further evaluate Scores for Newborn Gastrointestinal Functior (SNGF).Methods 60 newborns with moderate and severe HIE who were in the NICU of our department from June 2013 to December 2014 were collected.The 60 newborns were randomly divided into hypo-thermia treatment group (HG)and conventional treatment group(CG).The serum was collected and ELISA method was used to test the consistency of DAO on admission and 7 days afterwards,respectively.Meanwhile,the SNGF level of the two groups at the two time points was compared.Results Neither the DAO and SNGF level of the two groups had statistical difference on admission(all P >0.05).Seven days later,both the DAO of the two groups and the SNGF decreased[(12.51 ±1.53)u/mL vs (7.88 ±1.87)u/mL,however,the variation of the hypothermia treatment group was apparently more significant than the change of the conventional treatment group(P =0.011).The SNGF scores of the two groups all decreased,while the hypothermia treatment group was significantly lower than the conventional treat-ment group,the difference were statistically significant (P =0.044,0.006,0.013).Besides,there was remarkably positive correlation between serum DAO level and SNGF (r1 =-0.825,r2 =-0.876,all P <0.05).Conclusion Hypothermia treatment could effectively reduce the injury of asphyxia neonatal gastrointestinal tract by inhibiting the level of DAO,thus improve the gastrointestinal function.
