Evaluation of the Characteristics of Liver-kidney Yin Deficiency Syndrome in Late Stage of Spontaneously Hypertension Rats
10.3969/j.issn.1005-5304.2016.03.016
- VernacularTitle:晚期自发性高血压大鼠肝肾阴虚证候特征评价
- Author:
Zhichun WU
;
Huayun YU
;
Xuming JI
;
Bing OUYANG
- Publication Type:Journal Article
- Keywords:
combination of disease and syndrome;
animal model;
liver-kidney yin deficiency;
SHRs
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(3):58-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the characteristics of liver-kidney yin deficiency syndrome in late stage of spontaneously hypertension rats (SHRs). Methods Ten 12-month-old healthy male SHRs were put into syndrome observer group (SHR group), while ten male WKY rats with the same age were set as control group (WKY group). Syndrome differentiation method on rats was employed to transform the four-diagnostic information into general behavior indexes with the same significance. The afternoon anal temperature, tongue color, holding power, ability of learning and memory, serum estradiol and testosterone level were observed, compared and analyzed. Results Compared with the WKY group, rats in the SHR group had higher afternoon anal temperature, redder tongues, poorer strength and claw holding power and their ability of learning and memory was retarded; the level of serum estradiol was lower;the ratio of estradiol to testosterone was higher. All of these were largely in line with deficiency of live-kidney yin syndrome. Conclusion SHRs in late stage show characteristics of liver-kidney yin deficiency syndrome.
