Efficacy of Renal Artery Stenting Combining Optimal Drug Therapy in Patients With Atherosclerotic Renal Artery Stenosis
10.3969/j.issn.1000-3614.2016.02.006
- VernacularTitle:肾动脉支架置入术联合规范药物治疗对粥样硬化性肾动脉狭窄患者的疗效
- Author:
Bin LI
;
Meng PENG
;
Xiongjing JIANG
;
Hui DONG
;
Yubao ZOU
;
Lei SONG
;
Huimin ZHANG
;
Haiying WU
;
Yuejin YANG
;
Renlin GAO
- Publication Type:Journal Article
- Keywords:
Renal artery obstruction;
Stent;
Glomerular ifltration rate;
Drug therapy
- From:
Chinese Circulation Journal
2016;31(2):122-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluatethe efficacy of renal artery stenting combining optimal drug therapy in patients with atherosclerotic renal artery stenosis.
Methods:This is a prospective cohort study for patients who received percutaneous renal artery stenting in our hospital from 2011-09 to 2013-03. All patients had conifrmed diagnosis of atherosclerotic renal artery stenosis combing hypertension and/or renal functional damage. Thepatients received optimal drug therapy for anti-platelet and blood pressure, lipids, glucose controlling, and they were followed-up for at least 12 months to observe the improvement of blood pressure and renal function.
Results:There were 149 patients at the mean age of (61.54 ± 9.63) years and 185 renal artery stenosis with stent implantation;the average stenosis rate was (83.11±7.30)%and the success rate of operation was 99.32%(148/149). During follow-up period, the patients had increased estimated glomerular ifltration rate (GFR) compared to base line from (76.49 ± 22.50) ml/(min·1.73 m2) to (84.09 ± 28.79) ml/(min·1.73 m2), P<0.05 and decreased 24 h urinary protein from 0.1(IQR 0.02, 0.5) g to 0.04 (IQR0.01, 0.11)g, P<0.001;less type of drug therapy for hypertension from 2.22 to 1.56, P<0.05, decreased clinical and 24h dynamic systemic/diastolic blood pressure from (153.4 ± 15.6)/(83.77 ± 12.60) mmHg to (134.6 ± 14.4)/(73.57 ± 9.12) mmHg and from (143.32 ± 19.87)/(80.51 ± 11.33) mmHg to (124.44 ± 14.90)/(69.09 ± 9.49) mmHg, all P<0.05.
Conclusion:Renal artery stenting combining optimal drug therapy may improve blood pressure controlling and renal function in strictly selected patients with atherosclerotic renal artery stenosis.
