Relationship Between Leptin Receptor Gene Gln223Arg Polymorphism and Metabolism Syndrome With its Impact on Left Ventricular Hypertrophy
10.3969/j.issn.1000-3614.2016.02.007
- VernacularTitle:瘦素受体基因Gln223Arg多态性与代谢综合征的相关性及其对心脏结构功能的影响
- Author:
Hailing CHEN
;
Qian WANG
;
Jufen LI
;
Lili DENG
- Publication Type:Journal Article
- Keywords:
Receptors,leptin;
Polymorphism,mononucleotide;
Hypertrophy,Left ventricle;
Metabolism syndrome
- From:
Chinese Circulation Journal
2016;31(2):127-131
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship between 1eptin receptor gene Gln223Arg polymorphism and metabolism syndrome (MS) with its impact on cardiac structure and function.
Methods: Our research included 2 groups:MS group, n=167 patients with ifrst diagnosed MS without treatment in our hospital from 2005-10 to 2008-6 and Control group, n=216 healthy subjects from regular physical examination. Blood pressure, biochemical features, insulin levels and echocardiography were detected;leptin receptor Gln223Arg genotypes were measured by PCR-RFLP;the above indexes were compared between 2 groups.
Results:The patients in MS group had the higher frequency of A allele than Control group. The MS occurrence rate in allele A carrier was 3.302 times higher than allele G carrier (P=0.000;95%CI 2.432-4.483). The patients in MS group already had left ventricular hypertrophy and impaired diastolic function. Compared with MS G allele carriers, the A allele carriers had the higher BMI, blood pressure, glucose, fasting glucose and insulin levels, longer waist circumference, more serious dyslipidemia and insulin resistance, left ventricular hypertrophy and impaired diastolic function.
Conclusion: Leptin receptor gene Gln223Arg polymorphism is associated with the increased risk of MS occurrence and left ventricular hypertrophy.
