Impact of Alcohol Septal Ablation for Different Coronary Septal Branches on Cardiac Function in Experimental Canines
10.3969/j.issn.1000-3614.2016.02.016
- VernacularTitle:不同冠状动脉间隔支血管心肌化学消融对犬心脏功能的影响
- Author:
He WANG
;
Junmeng WANG
;
Dan SUN
;
Yonghua ZONG
;
Wenjie DONG
;
Jinhong XIE
;
Yushan CHEN
;
Minghua LUO
;
Huaimin GUAN
- Publication Type:Journal Article
- Keywords:
Cardiomyopathy,hypertrophic;
Ablation Techniques;
Canine
- From:
Chinese Circulation Journal
2016;31(2):170-174
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the percutaneous transluminal septal myocardial ablation (PTSMA) and percutaneous transluminal septal tunnel myocardial ablation (PTSTMA) on cardiac function in experimental canines.
Methods: According to CAG determined coronary septal branches, a total of 25 hybrized canines were divided into 2 groups:PTSMA group, n=13 canines with the bigger septal branches and PTSTMA group, n=12 canines with the smaller or uneven septal branches. Alcohol ablation model was established. Electrocardiograph (ECG) at before and after the operation, biomarkers for myocardial injury, echocardiography and hemodynamic changes were recorded. The animals were scariifes at 1 week after operation, the pathological changes in ventricular septal were observed by HE and Masson staining.
Results: Myocardial infarction (MI) could be induced by either PTSMA or PTSTMA and the thickness of septal was decreased. LVEDd, LVEF and hemodynamic indexes were similar between 2 groups. The alcohol volume used in operation, EKG and echocardiography ifndings were similar between 2 groups, P>0.05. Pathological staining indicated that there was a well-demarcate between the ablation focal and normal myocardium, merging area had neutrophiles invasion, infarcted cells were partially having the ghost cell sample and they were gradually replaced by ifbrous tissue. There was nest-like necrosis in ablated lumen and the normal vessel wall disappeared. PTSMA group had vessel lumen conifguration in septal branch and the necrosis limited inside the lumen;while in PTSTMA group, the vessel wall of was discontinued and some necrosis materials move out to from lumen.
Conclusion: Both PTSMA and PTSTMA were effective for alcohol septal ablation in different coronary septal branches, the impacts on cardiac function and hemodynamic changes were similar in experimental canines.
