Feasibility Study on Test Method Establishment for Histamine-like Substances in Pirarubicin
- VernacularTitle:吡柔比星组胺类物质检查法建立的可行性考察
- Author:
Yi LU
;
Jingwen XIAN
;
Runhua CHEN
;
Meirong QIN
;
Xiaowei WANG
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
Pirarubicin;
Histamine-like substances;
Test
- From:
China Pharmacist
2016;19(2):402-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish the test method for histamine-like substances in pirarubicin. Methods:According to the meth-od described in the appendix of Chinese Pharmacopoeia (2010 edition), the test for histamine-like substances was carried out. Re-sults:The test for histamine-like substances had no interference under the condition with pirarubicin concentration of 0. 01mg·ml-1 . The established test method for histamine-like substances in pirarubicin was applied in 10 samples, and the results were accordant with those of the test method for depressor substances. Conclusion:The test method for histamine-like substances in pirarubicin is feasible with the limit of 1 μg·mg-1 .
