"Study on wilforlide A before and after compatibility according to ""conteract the toxicity of another drug"""
10.3760/cma.j.issn.1008-6706.2016.02.002
- VernacularTitle:雷公藤相杀、相畏配伍后雷公藤内酯甲的研究
- Author:
Po XU
;
Mei MENG
;
Jing ZHANG
;
Ying JIANG
;
Liyu TANG
- Publication Type:Journal Article
- Keywords:
Tripterygium;
Astragalus Membranaceus;
Drug Incompatibility
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(2):166-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the synergistic mechanism of compatibility of Tripterygium Wilfordii and Astragalus,and to determine wilforlide A before and after compatibility.Methods To research Tripterygium Wilfordii single medicinal materials,Tripterygium Wilfordii compatibility of Astragalus and Tripterygium Wilfordii reference substance using the HPLC method,so as to provide further verification by the change of wilforlide A.Results The content of wilforlide A was 0.00 324% by measuring Tripterygium Wilfordii single medicinal materials.The content of wilforlide A was 0.00 184% by measuring Tripterygium Wilfordii compatibility of Astragalus.Conclusion The content of wilforlide A was decreased before and after compatibility and toxicity can be reduced.The synergistic mech-anism of the compatibility of Tripterygium Wilfordii and Astragalus is conteract the toxicity of another drugin posse.
