The application of mifepristone combined with misoprostol in the treatment of placenta adherence
10.3760/cma.j.issn.1008-6706.2016.02.017
- VernacularTitle:米非司酮联合米索前列醇在胎盘粘连治疗中的应用
- Author:
Jie LU
- Publication Type:Journal Article
- Keywords:
Mifepristone;
Misoprostol;
Placenta adherence
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(2):223-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of mifepristone combined with misoprostol on the pla-centa adherence.Methods 80 cases with placenta adherence were randomly selected and divided into control group and treatment group.The treatment group was treated with mifepristone and misoprostol,while the control group was given oxytocin by intravenous injection.In addition,patients of two groups were orally given Shenghua Tang once dai-ly.The vaginal bleeding of all the patients were measured within 12h,24h and 72h after the parturition.In addition, the time when the placenta was expelled out of the uterus was also recorded.After the clinical treatment,standardized protocols were closely followed for all patients to record the vaginal bleeding.B -mode ultrasound was used to observe the uterine reversion and determine whether there were intrauterine residues.Results The vaginal bleeding of the two groups had no significant difference within 12h and 24h.But after 72h,the vaginal bleeding of the treatment group was less(t =2.436,P <0.05).What's more,it take 3 -7 days to expel the placenta out of the uterus in the treatment group,while 11 -13 days in the control group.And the cure rate of the control group was only 77.5%,but that of the treatment group was increased to 95.0%(χ2 =5.165,P <0.05).Conclusion The combination of mifepristone and misoprostol has therapeutic efficacy to the placenta adherence,which is worthy of clinic application.
