Relationship Between Pulmonary Function and Coronary Artery Disease With the Severity of Coronary Lesions in Relevant Patients
10.3969/j.issn.1000-3614.2016.01.012
- VernacularTitle:肺功能与冠心病及其冠状动脉病变严重程度的相关性
- Author:
Qiong ZHANG
;
Jiangwei MA
;
Jianhua HUANG
;
Yong GONG
;
Zengyong QIAO
;
Sanjun XIONG
;
Guanghao GE
- Publication Type:Journal Article
- Keywords:
Forced expiratory volume;
Natriuretic peptide,brain;
Heart function tests;
Gensini Score
- From:
Chinese Circulation Journal
2016;31(1):55-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between pulmonary function and coronary artery disease (CAD) with the severity of coronary artery lesions in relevant patients.
Methods:A total of 200 patients received coronary angiography (CAG) in our hospital were studied. The patients were divided into 2 groups: Non-CAD group, n=88 and CAD group, n=112. The degree of coronary stenosis was assessed by GENSINI score;the pulmonary function, echocardiography and fasting blood level of brain natriuretic peptide(BNP) were examined in all patients.
Results:Forced expiratory volume in 1 second (FEV1) in CAD group (2.33±0.54) L/1s was lower than Non-CAD group (2.63±0.39) L/1s, P=0.04. Multivariate logistic regression analysis indicated that decreased FEV1 was the independent risk factor for CAD (OR=2.9, 95%CI 1.89-4.23, P<0.01). Spearman correlation analysis showed that FEV1 was negatively related to blood level of BNP (r=-0.54, P<0.01), positively related to the ratio of E/A (r=0.27, P=0.03). GENSINI score was positively related to smoking (r=0.31, P=0.01), diabetes (r=0.19, P=0.03) and negatively related to FEV1 (r=-0.40, P<0.01). With adjusted variables, partial correlation analysis presented that FEV1 was negatively related to GENSINI score (r=-0.21, P=0.01).
Conclusion:Decreased FEV1 is not only related to CAD occurrence, but also related to the degree of coronary stenosis in relevant patients.
