Relationship Between Plasma Levels of Soluble Receptor of Advanced Glycosylation End Products and Cardiac Function in Patients With Sepsis
10.3969/j.issn.1000-3614.2016.01.016
- VernacularTitle:脓毒症患者血浆可溶性晚期糖基化终末产物受体水平与心功能的关系
- Author:
Luanluan ZHANG
;
Qiqun WANG
;
De CHEN
;
Rong ZHOU
- Publication Type:Journal Article
- Keywords:
Sepsis;
Natriuretic peptide,brain;
Heart function tests;
Glycosylation end product,advenced
- From:
Chinese Circulation Journal
2016;31(1):73-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship between plasma levels of soluble receptor of advanced glycation end products (sRAGE), brain natriuretic peptide (BNP) and cardiac function in patients with sepsis.
Methods: A total of 83 sepsis patients treated in our hospital from 2014-01 to 2015-06 were studied. Plasma levels of sRAGE, BNP were examined at 24 h after admission and they were evaluated by APACHEII scores. According to BNP levels, the patients were divided into 2 groups:Normal cardiac function group, the patients with BNP<500 pg/ml, n=32 and Cardiac dysfunction group, the patients with BNP≥500 pg/ml, n=51. The cardiac function as stroke volume (SV), LVEF, minute volume, E/A were examined by echocardiography. The above indexes were analyzed and compared between 2 groups, the relationship between plasma levels of sRAGE and the occurrence of sepsis was assessed by Logistic regression analysis.
Results: Compared with Normal cardiac function group, the patients in Cardiac dysfunction group presented decreased SV, LVEF, minute volume and E/A;increased APACHEII scores and sRAGE, all P<0.01. Plasma levels of sRAGE in sepsis patients were positively related to BNP (r=0.90, P<0.05) and APACHEII scores (r=0.85, P<0.05). Logistic regression analysis indicated that plasma levels of sRAGE (OR=1.019, 95%CI 1.004-1.035, P<0.05) was independently related to cardiac function in patients with sepsis.
Conclusion: Plasma levels of sRAGE were independently related to cardiac function in patients with sepsis.
