Preparation of Celecoxib Nanostructured Lipid Carriers and Tissue Distribution in Rats
- VernacularTitle:塞来昔布纳米结构脂质载体的制备及大鼠组织分布研究
- Author:
Qiuyan LI
;
Min WANG
;
Peng XIE
;
Yanrong DAI
- Publication Type:Journal Article
- Keywords:
Celecoxib;
Nanostructured lipid carriers;
Tissue distribution;
Melt-emulsion ultrasonication and low temperature-so-lidification method
- From:
China Pharmacist
2016;19(2):277-281
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare celecoxib nanostructured lipid carriers and investigate the characteristics of tissue distribution in rats. Methods:Celecoxib nanostructured lipid carriers were prepared by a melt-emulsion ultrasonication and low temperature-solidifi-cation method. The physicochemical properties of nanostructured lipid carriers were studied, such as particle size distribution, zeta po-tential and morphology. The concentration of celecoxib in different tissues was determined after tail vein injection of celecoxib nano-structured lipid carriers in rats. Results:The obtained celecoxib nanostructured lipid carriers were spherical with the average particle size of (103. 5 ± 32. 6) nm and zeta potential of ( -37. 3 ± 5. 1) mV. The re of celecoxib nanostructured lipid carriers in liver, spleen, brain and muscle respectively was 3. 43, 2. 99, 2. 38 and 2. 93 times higher than that of celecoxib injection. Conclusion:The biodistribution of celecoxib is changed by the nanostructured lipid carriers. Celecoxib nanostructured lipid carriers have the characteris-tics of liver, spleen and muscle targeting, which is benefit to improving the efficacy.
