Preparation, Quality Control and Stability of Docetaxel Liposomes Mediated by Folic Acid Receptor
- VernacularTitle:叶酸介导的多西他赛脂质体制备、质量控制及稳定性研究
- Author:
Dengshan ZHANG
;
Liucheng LIU
- Publication Type:Journal Article
- Keywords:
Folic acid;
Docetaxel;
Liposomes;
Preparation;
Quality control;
Stability
- From:
China Pharmacist
2016;19(2):282-286
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare docetaxel liposomes mediated by folic acid receptor using different preparation processes, estab-lish the quality control and determine the stability. Methods:HSPC, FA-PEG2000-DSPE and docetaxel were dissolved in the solvent with the ratio of 100︰5︰8. Docetaxel liposomes were prepared by three different methods. The mean diameter of liposomes was deter-mined by dynamic light scattering (DLS). Low-speed centrifugation was employed to determine the encapsulation efficiency (EE). The residual organic solvents were determined by gas chromatograph. Results:The mean diameter of docetaxel liposomes was (155 ± 10) nm with PdI below 0. 20. The EE was over 95. 0%. The inspection indices of docetaxel liposomes were not changed significantly after six-month storage under the temperature of (25 ± 2)℃. Conclusion:The third production process with high ratio of drug to lipid is feasible, controllable and stable in quality.
