Influence of Rosuvastatin Intensive Lipid-Lowering on Oxidative Stress in the Patients with Unstable Angi-na Pectoris (UAP)
- VernacularTitle:瑞舒伐他汀强化调脂对不稳定型心绞痛患者氧化应激的影响
- Author:
Yi TIAN
- Publication Type:Journal Article
- Keywords:
Unstable angina pectoris;
Rosuvastatin;
Intensive lipid-lowering;
Oxidative stress
- From:
China Pharmacist
2016;19(2):290-291
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the influence of rosuvastatin intensive lipid-lowering on oxidative stress in the patients with un-stable angina pectoris ( UAP) . Methods:Totally 92 cases of patients with UAP were divided into the observation group and the control group at random with 46 cases in each. The patients in the two groups were given aspirin,β-blocker, nitrate preparations, angiotensin converting enzyme inhibitor ( ACEI) and the other basic medical treatment, and the patients in the control group were additionally giv-en 10mg rosuvastatin, qd, before sleeping, while the patients in the observation group were additionally given 20mg rosuvastatin, qd, before sleeping, and the course of treatment was 8 weeks. The changes of serum SOD, MDA and LPO levels in the two groups before and after the treatment were observed, and the adverse drug reactions ( ADR) were compared as well. Results: The rate of follow-up loss of the two groups had no statistically significant difference (P>0. 05). After the 8-week treatment, the serum MDA and LPO lev-els of the patients were obviously declined, while the SOD levels were obviously increased in the two groups (P<0. 05 or P<0. 01), and the changes in the observation group were more notable than those in the control group (P<0. 05). The incidence of ADR in the two groups had no statistically significant difference (P>0. 05). Conclusion:Rosuvastatin intensive lipid-lowering has high security. The mechanism may closely related to the effects of reducing serum MDA and LPO levels, increasing SOD levels, inhibiting lipid per-oxidation and enhancing antioxidant capacity.
