Research Progress in Absorption Evaluation Methods for Pulmonary Delivery
- VernacularTitle:肺部给药吸收评价方法的研究进展
- Author:
Liying SHI
;
Jingling TANG
;
Yanan GAO
;
Qingli MENG
;
Lijun WU
- Publication Type:Journal Article
- Keywords:
Pulmonary delivery;
Absorption evaluation;
In vitro cell models;
In vitro pulmonary membrane model;
In vivo animal models
- From:
China Pharmacist
2016;19(2):341-343
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To review the drug absorption evaluation methods for pulmonary delivery. Methods: The drug absorption cell models, in vitro pulmonary membrane model and in vivo animal model were systematically summarized, and the advantages and disadvantages of those models and applications were reviewed by referring to the databases in CNKI and Pubmed. Results:The appro-priate animal model and method for the study of pulmonary absorption should be chosen according to the experimental purpose and char-acteristics of drugs. Conclusion:The review provides the thoughts and theoretical basis for the research and development of pulmonary delivery.
