mTOR signaling pathway and bronchopulmonary dysplasia
10.3760/cma.j.issn.1673-4408.2016.01.011
- VernacularTitle:mTOR信号通路与支气管肺发育不良
- Author:
Dongmei ZOU
;
Shaohua WANG
- Publication Type:Journal Article
- Keywords:
mTOR signaling pathway;
Bronchopulmonary dysplasia;
Lung development;
Acute lung in-jury;
Lung fibrosis
- From:
International Journal of Pediatrics
2016;43(1):41-44
- CountryChina
- Language:Chinese
-
Abstract:
mTOR signaling pathway is a highly conserved intracellular signaling pathway,which partici-pates in several signaling pathways, such as PI3K/AKT/mTOR, AKT/TSC1-TSC2/Rheb/mTOR, LKB1-AMPK-TSC-mTOR and FGF-10-Spry2-mTORC1-STAT3/HIF-1α-VEGF-A. mTOR signaling implicate in the regulation of the development of lung and many pulmonary diseases in many aspects,may be connected to bron-chopulmonary dysplasia. Bronchopulmonary dysplasia is one of the very common chronic lung diseases in pre-term,physical and chemical factors have been shown to induce acute lung injury, aberrant wound healing and lung fibrosis in the immature lung. This review summarizes relationship of mTOR signaling among lung develop-ment,acute lung injury and lung fibrosis,to explore the role of mTOR signaling in the development of bronchop-ulmonary dysplasia,in hope of providing novel method in the prevention and treatment of bronchopulmonary dysplasia.
