The role of PAX2 in acute kidney injury and chronic kidney disease
10.3760/cma.j.issn.1673-4408.2016.01.016
- VernacularTitle:PAX2与急慢性肾脏疾病研究进展
- Author:
Xiuli WANG
;
Chengguang ZHAO
;
Yubin WU
- Publication Type:Journal Article
- Keywords:
PAX2;
Acute kidney injury;
Chronic kidney disease
- From:
International Journal of Pediatrics
2016;43(1):59-63
- CountryChina
- Language:Chinese
-
Abstract:
Paired box2 ( PAX2 ) is a transciption factor which mainly expressed in the developing kid-ney. Researches indicate that PAX2 promote the transcription through interactions with the adaptor PAX transac-tivation domain interacting protein(PTIP). Otherwise,PAX2 protein can lead to chromatin compaction and gene silencing through interactions with Grg4. PAX2 reexpressed in acute kidney injury and involved in promoting cell proliferation. Congenital PAX2 gene mutation is closely related to congenital abnormalies of the kidney and uri-nary tract. In chronic kidney disease,PAX2 promote proliferation and cyst formation. Here,the recent researches on the function of PAX2 and its role in acute kidney injury and chronic kidney disease are reviewed.
