Sepsis and mitochondrial function damage
10.3760/cma.j.issn.1673-4408.2016.01.019
- VernacularTitle:脓毒症与线粒体功能障碍
- Author:
Xue YANG
;
Xiaodi CAI
;
Guoping LU
- Publication Type:Journal Article
- Keywords:
Sepsis;
Mitochondrial damage;
Mitochondrial autophagy
- From:
International Journal of Pediatrics
2016;43(1):70-73
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a complex systemic inflammatory response syndrome caused by invasion of a varie-ty of pathogenic bacteria. The disease spectrum includes sepsis, severe sepsis, septic shock and multiple organ failure. Mitochondria are referred to as “power plants”, providing energy for viscera to maintain normal func-tion. Immune disorders,the activation and release of a series of inflammatory factors,anomalies of intracellular signal transmission and oxidative stress in sepsis can induce mitochondrial dysfunction. Recent research suggests that mitochondrial autophagy also plays a certain role in mitochondrial dysfunction. This article reviews the mechanism of mitochondrial functional damage during the pathogenesis of sepsis.
