The application and research progress of whole-genome sequencing in clinical microbiology detection
10.3760/cma.j.issn.1009-9158.2016.04.020
- VernacularTitle:全基因组测序在病原微生物学中的应用及研究进展
- Author:
Menglan ZHOU
;
Yingchun XU
;
Yupei ZHAO
- Publication Type:Journal Article
- Keywords:
Microbiological techniques;
Genomics;
Sequence analysis;
Metagenomics;
Single-cell analysis
- From:
Chinese Journal of Laboratory Medicine
2016;39(4):319-321
- CountryChina
- Language:Chinese
-
Abstract:
Whole-genome sequencing of bacteria has recently emerged as a cost-effective and convenient approach for resolving many microbiological questions.Here, the current status of whole-genome sequencing in clinical microbiology and the main problems that exist were reviewed, focusing on six essential tasks: identifying and culturing the species of an isolate, rapid identification of pathogen properties, monitoring the emergence and spread of an epidemic outbreak, developing vaccine and monitoring its variation,metagenomics and single-cell sequencing.The authors predicted that the application of whole-genome sequencing will soon be sufficiently fast, accurate and cheap to be used in routine etiological detection, even though there is still a long way to go.
