Functional regulation of adipocytes and adipose tissue remodeling
10.3760/cma.j.issn.1000-6699.2016.04.020
- VernacularTitle:脂肪细胞的功能调节与脂肪组织重构
- Author:
Dufang MA
;
Xiao LI
- Publication Type:Journal Article
- Keywords:
Brown adipose tissue;
Beige cell;
Browning of white adipose tissue;
Pathological fat expansion
- From:
Chinese Journal of Endocrinology and Metabolism
2016;32(4):341-345
- CountryChina
- Language:Chinese
-
Abstract:
Adipocytes are classified into three types, including white, brown, and “beige/brite” adipocytes. There exist differences in origin of adipocytes, gene expressions, morphology, and functions among three kinds of adipocytes. Multiple factors such as physical and chemical factors, neurohormonal and immunological factors, transcriptional factors have been shown to regulate and control the browning process and lipolysis of white adipose tissue. Thus, they may become new targets for anti-obesity intervention. In the process of obesity, chronic inflammation reaction, adipose tissue remodeling and abnormal angiogenesis occurring in the adipose tissue cause pathological fat expansion and reduce lipid storage in adipocytes. Understanding adipocytes biology is important to decipher how the aberrant adipose tissue contributes to obesity and metabolic disorders, and provides guidance for treating obesity.
