Genomic instability and its detection technologies for clinical application in cancer patients
10.3760/cma.j.issn.1009-9158.2016.04.018
- VernacularTitle:基因组不稳定性及其相关检测在肿瘤诊疗中的应用进展
- Author:
Renquan LU
;
Lin GUO
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Genomic instability;
Telomere;
DNA damage;
DNA repair
- From:
Chinese Journal of Laboratory Medicine
2016;39(4):311-314
- CountryChina
- Language:Chinese
-
Abstract:
Carcinogenesis is a multistep process that a couple of genes involve in the initiation of this disease.As a pivotal hallmark of cancer, the genomic instability ensues in which genetic alterations when this process was initialized and developed. With the increasing number of studies on genomic instability, the scientists pay more attentions on its biological function at post-genomic era. Genomic instability in various carcinomas is associated with broken telomere, gene modification, and contributes to the dysfunction of DNA damage and repair pathways.This review focus on the factors involved in genomic instability, as well the current detection methods of genomic instability and their clinical application.
