Correlations between the Expressions of SRSF1 and Survivn and the Pathological Features of Prostate Cancer
10.12007/j.issn.0258-4646.2016.05.018
- VernacularTitle:SRSF1和Survivin在前列腺癌组织中的表达及其与病理分级的相关性
- Author:
Bangming XIAO
;
Xingwang ZHU
;
Liming DONG
;
Yili LIU
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
prostate cancer;
benign prostatic hyperplasia;
serine/arginine rich splicing factor 1;
Survivin;
immunohistochemical
- From:
Journal of China Medical University
2016;45(5):452-455
- CountryChina
- Language:Chinese
-
Abstract:
Objective To test the expression of serine/arginine rich splicing factor 1(SRSF1)and apoptosis inhibiting factor(Survivin) in prostate cancer,and study their correlation with the pathological features of prostate cancer,so as to put forward the new targets in the treatment of prostate cancer. Methods SRSF1 and Survivin protein was determined in 20 prostate tissue samples including prostate cancer(n=12)and benign prostat?ic hyperplasia(n=8)by immunohistochemical SP method. SRSF1 and Survivin was correlated to pathological features,and both the relevance was analyzed(no related reports at home and abroad). Results The positive expression rate of SRSF1 protein in prostate cancer tissue cells was 76.37± 5.06%,which was significantly higher than that of benign prostatic hyperplasia(11.30%±1.09%,P<0.05);the positive expression rate of Survivin protein in prostate cancer tissue cells was 86.93%±3.21%,which was significantly higher than that of benign prostatic hyperplasia(17.67%±1.99%, P<0.05);SRSF1 and Survivin protein expressed in prostate cancer organizations and were positively correlated to pathological Gleason grading, and there was significant correlation(P<0.05). Conclusion SRSF1 and Survivin protein were highly expressed in adenocarcinoma tissue,which were significantly increased than that of benign hyperplasia of prostate tissue. The positive expression SRSF1 and Survivin protein were positively cor?related to pathological Gleason grading.The expression of Survivin protein was elevated with the expression of SRSF1 protein in prostate cancer. These preliminary evidence indicated that SRSF1 may up?regulate the expression of Survivin,and thus promote the occurrence and development of prostate cancer.
