Clinical Significance of Urinary Kidney Injury Molecule-1,Serum Cystatin C and Urinary Neutrophil Gelatinase-associated Lipocalin in the Prediction of Early Kidney Damage in Preeclampsia
10.12007/j.issn.0258-4646.2016.05.020
- VernacularTitle:尿肾损伤分子1、血清胱抑素C和尿中性粒细胞明胶酶相关性脂质运载蛋白预测子痫前期发病和早期肾损伤的价值
- Author:
Jing HUANG
;
Meiling ZHENG
;
Yujue WANG
;
Ting YU
- Publication Type:Journal Article
- Keywords:
preeclampsia;
kidney injury molecule-1;
serum cystatin C;
lipocalin,neutrophil gelatinase-associated
- From:
Journal of China Medical University
2016;45(5):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum cystain C,urinary neutrophil gelatinase?associated lipocalin(NGAL),uri?nary kidney injury molecule?1(KIM?1)and preeclampsia,and explore the value in predicting preeclampsia and early kidney damage. Methods A total of 30 cases of pregnant women with severe preeclampsia,30 cases of mild preeclampsia and 60 cases of healthy pregnant women admitted in the Second Hospital of Jilin University from October 2014 to July 2015 were enrolled for the study. ELISA was performed to check urinary KIM?1 and urinary NGAL,and the serum cystatin C was detected by immune turbidity method. Results KIM?1,NGAL,serum cystatin C in the preeclampsia were significantly higher than the normal control group(P<0.05). In addition,with the development of their concentrations,the progression of pre?eclampsia gradually rise;BMI,e?GFR,urine protein/creatinine ratio,KIM?1,serum scystatin C and NGAL are the risk factors for preeclampsia;uKIM?1,serum scystatin C and NGAL and combined predictors of preeclampsia are taken as the early indicators of renal injury,which sensitivity are separately 83.3%,75%,88.9%,96.8%;specificity are respectively 72.7%,70%,75.6%,86.4%. Conclusion KIM?1,serum scystatin C and NGAL may reflect the progression of renal injury in preeclampsia .Combined predictors have a higher predictive value in the early renal injury of the preeclampsia.
