Correlation of CCR5 expression with β-arrestin 2 expression in colonic mucosa of patients with inflammatory bowel disease
10.3969/j.issn.1000-4718.2016.04.022
- VernacularTitle:CCR5在炎症性肠病患者肠黏膜的表达及其与 β-arrestin 2表达的关系
- Author:
Xiaoyan YE
;
Sixue LIU
;
Mei HU
;
Ximing SHEN
;
Huarong HUANG
;
Yingqiang ZHONG
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
CCR5;
β-arrestin 2
- From:
Chinese Journal of Pathophysiology
2016;32(4):713-718
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To analyze the expression of CCR5 and correlation with the expression ofβ-arrestin 2 in the intestinal mucosa of the patients with inflammatory bowel disease ( IBD) , so as to study the role of CCR5 andβ-arrestin 2 in the pathogenesis of IBD.METHODS:Paraffin sections of the colonic mucosa were prepared from 53 patients with active IBD, 26 patients with remissive IBD and 30 healthy people.Immunohistochemical EnVision two-step method was used to test the expression of CCR5 andβ-arrestin 2 in the biopsic intestinal mucosa.RESULTS:The positive rate, strongly posi-tive rate and immunohistochemical score of CCR5 expression in active IBD were significantly higher than those in normal controls or remissive IBD (P<0.05).No correlation of CCR5 expression with clinical severity, lesion distribution, and endoscopic grade in active IBD was observed.The expression ofβ-arrestin 2 was significantly lower in active IBD than that in the remissive IBD and normal controls, and there was a negative correlation ofβ-arrestin 2 expression with CCR5 expres-sion (P<0.05).CONCLUSION:The expression of CCR5 is higher, and expression ofβ-arrestin 2 is lower, and there is a negative correlation of expression of CCR5 with expression ofβ-arrestin 2 in intestinal mucosa of the active IBD.
