DNA methylation of oxidative metabolic enzymes:research progres
10.3867/j.issn.1000-3002.2016.04.016
- VernacularTitle:氧化代谢酶DNA甲基化研究进展
- Author:
Siyuan ZHOU
;
Jianan HU
;
Can HUANG
- Publication Type:Journal Article
- Keywords:
DNA methylation;
cytochrome P-450 enzyme system;
lipoxygenase;
cyclooxygen-ase 2;
monoamine oxidase
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(4):405-414
- CountryChina
- Language:Chinese
-
Abstract:
DNA methylation is part of the epigenetic modification process,which can lead to aberrant gene expression. Cytochrome P450 enzyme,cyclooxygenase,lipoxygenase and monoamine oxidase are a class of enzymes produced by human tissues,which are involved in the oxidization pro?cess of endogenous and exogenous chemicals. The methylation patterns of these enzyme genes are dif?ferent between normal tissues and pathological ones. Abnormal methylation patterns will change en?zymes′expression and function,and affect the occurrence and development of diseases. This paper re?viewed the characteristic changes of four oxidative metabolic enzyme genes in certain diseased tis?sues,the impact on methylation status of the metabolic activity of chemicals and on human health. It is hoped that this review can provide a new theoretical basis for the study on the toxic mechanism of chemicals and for diagnosis of diseases.
