Analysis of Clinical Significance of AKT3 Expression in Gastric Cancer Utilizing TCGA Datasets

VernacularTitle:利用TCGA数据集分析AKT3在胃癌中的表达及临床意义
Author: Shuo WANG ; Zhi LI ; Chunlei ZHENG ; Xiujuan QU ; Jing LIU ; Jinglei QU ; Xiaofang CHE ; Yunpeng LIU
Publication Type:Journal Article
Keywords: gastric cancer; cancer genome atlas; AKT3; prognosis
From: Journal of China Medical University 2016;45(5):398-401
CountryChina
Language:Chinese
Abstract: Objective To investigate the prognostic value of AKT3 expression in gastric cancer. Methods AKT3 expression data in The Cancer Genome Atlas(TCGA)datasets and its clinical information were downloaded. Statistically assessed was performed for relationship with clinicopatho?logical factors and prognosis. Gene set enrichment analysis(GSEA)was used to predict the gene sets modulated by AKT3. Results The expres?sion of AKT3 was associated with T stage(P=0.001),TNM stage(P=0.049)and differentiation(P<0.001).High level of AKT3 expression indi?cates poor prognosis(P=0.001). AKT3 could regulate gene sets involving cell adhesion molecule,cytoskeleton regulation,focal adhesion and TGF?βsignaling pathway. Conclusion AKT3 could be used as a potential prognostic marker and a therapeutic target in gastric cancer.