Correlation of Serum Cholinesterase Level with the Severity and Prognosis of Acute Cerebral Infarction
10.12007/j.issn.0258-4646.2016.05.009
- VernacularTitle:血清胆碱酯酶水平与急性脑梗死病情严重程度及预后的相关性
- Author:
Chunyao LI
;
Weixin SI
;
Yue ZHAO
;
Guowen WANG
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
cholinesterase;
cerebral infarction;
prognosis;
infarct size;
mRS score
- From:
Journal of China Medical University
2016;45(5):417-421
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of serum cholinesterase(CHE) level with the severity and prognosis in patients with acute cerebral infarction. Methods A total of 325 patients with acute cerebral infarction were recruited as patients group,and another 101 healthy sub?jects were selected as control group. Velocity method was employed to detect the level of serum CHE. Patients with acute cerebral infarction were then divided into different groups according to the infarcts diameter and the modified Rankin scale(mRS)at 1 year post stroke. The collected data were analyzed statistically. Results The level of serum CHE in small and medium area infarction group was higher than control group(P<0.01);the level of serum CHE in large area infarction group was lower than control group(P<0.01);the level of serum CHE was negatively correlated with infarct size,NIHSS and the mRS score(r=-0.302,-0.232,-0.455,P<0.001). The level of CHE,age,NIHSS and infarcts diameter was identified as independent influence factors for prognosis of acute cerebral infarction. Conclusion Early phase of serum CHE level is closely related with the infarct size and illness severity index in patients with acute cerebral infarction,which could be an independent factor affecting the prognosis of cere?bral infarction.
