VEGF and VEGFR Expressions in Non-small Cell Lung Cancer with Malignant Pleural Effusion

VernacularTitle:血管内皮生长因子及其受体在伴恶性胸腔积液非小细胞肺癌组织中的表达
Author: Yuan WANG ; Ye TIAN ; Siyang LIU ; Xitong ZHAO ; Wenjun JIANG ; Dali TIAN
Publication Type:Journal Article
Keywords: vascular endothelial growth factor; vascular endothelial growth factor receptor; non-small cell lung cancer; malignant pleu-ral effusion
From: Journal of China Medical University 2016;45(5):441-444
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of VEGF and VEGFR in non?small cell lung cancer patients with malignant pleural effusion, and analyze the relationship between VEGF and VEGFR and malignant pleural effusion. Methods The VEGF and VEGFR expression were detect?ed using immunohistochemistry in pleural and lung tumors tissues of 30Ⅳstage non?small cell lung cancer patients,and the relationship between VEGF and VEGFR expression and malignant pleural effusion was analyzed. Results The expression of VEGF and VEGFR in pleural tissue of pa?tients with malignant pleural effusion was significantly higher than those without malignant pleural effusion(P<0.05). Conclusion There is a very close correlation between high expression of VEGF and VEGFR and formation of malignant pleural effusion.