Correlation between blood pressure variability and hemorrhagic transformation in patients with cardioembolic middle cerebral artery occlusion
10.3760/cma.j.issn.1673-4165.2016.03.002
- VernacularTitle:血压变异性与心源性大脑中动脉栓塞患者出血性转化的相关性
- Author:
Yihui LIU
;
Xinjiang ZHANG
;
Tieyu TANG
;
Jiangbing LIU
;
Lihong TAO
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Infarction,Middle Cerebral Artery;
Cerebral Hemorrhage;
Atrial Fibrilation;
Blood Pressure;
Risk Factors
- From:
International Journal of Cerebrovascular Diseases
2016;24(3):198-204
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between hemorrhagic transformation (HT) and each parameter of blood pressure variability (BPV) in patients with massive cerebral infarction caused by cardioembolic middle cerebral artery occlusion. Methods The patients with massive cerebral infarction caused by unilateral cardioembolic middle cerebral artery occlusion admitted to hospital within 24 h after onset were selected. For patients without revealing HT with head MRI on admission were analyzed retrospectively. According to the results of MRI rescan within 7 days after onset, they were divided into either a HT group or a non-HT group. Al specific parameters of blood pressure were compared and analyzed between the 2 groups, specificaly including initial value (initial), mean value ( mean), maximum value (max), minimum value (min), maximum-minimum difference (max-min), standard deviation (sd), successive variation (sv), and maximum value of sv (svmax) of systolic blood pressure (SBP) and diastolic blood pressure (DBP). Results A total of 146 patients were enroled in the analysis, and 77 (52. 7% ) had HT within 7 d after onset. Al the blood pressure parameters were grouped by quartiles. Multivariate logistic regression analysis showed that after adjusting for age, admission time, baseline National Institutes of Health Stroke Scale score, congestive heart failure, antiplatelet therapy, initial blood glucose, prothrombin time, and international normalized ratio of the patients, SBPmin , SBPmax-min , SBPsv , SBPsvmax , DBPinitial, DBPsd , DBPmax , DBPmax-min , DBPsv , and DBPsvmax had significant independent association with and HT (likelihood ratio test of trend, al P < 0. 05). Conclusions Higher BP level and variability may increase the risk of HT in patients with massive cerebral infarction after cardioembolic middle cerebral artery occlusion. A smooth and slow antihypertensive treatment may need for these patients.
