Safety evaluation of inhaled nitric oxide in treatment of bronchopulmonary dysplasia
10.3760/cma.j.issn.1673-4912.2016.04.007
- VernacularTitle:长期吸入低浓度一氧化氮在支气管肺发育不良治疗中的安全性研究
- Author:
Qiufen WEI
;
Yan LI
;
Xinnian PAN
;
Danhua MENG
;
Xianzhi LIU
;
Jing XU
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
Nitric oxide;
Bronchopulmonary dysplasia;
Preterm infant
- From:
Chinese Pediatric Emergency Medicine
2016;23(4):244-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the safety of inhaled nitric oxide (iNO)for bronchopulmonary dysplasia (BPD).Methods We analysed 65newborns diagnosed as BPD from January 2012to December 2013in Maternal and Child Health Hospital of the Guangxi Zhuang Autonomous Region.They were divided into iNO group(n=35)and control group(n=30)according to whether administering iNO or not.The heart rate,blood pressure,oxygen supply time,assisted ventilation time,hospital stay,concentration of NO2 and methemoglobin,and the changes of coagulation function were observed dynamically before and after iNO treatment.Results There were significant differences in oxygen supply time[(37±9)d vs.(55±7)d], assisted ventilation time[(29±7)d vs.(35±9)d],hospital stay [(45±9)d vs.(54±7)d]between iNO group and control group(P﹤0.05).There were no obvious changes in heart rate,blood pressure and co-agulation function before and after iNO treatment(P﹥0.05).The incidences of the complications had no sig-nificant differences between the two groups (P﹥0.05).Conclusion Long-time iNO can shorten oxygen therapy time and assisted ventilation time,iNO therapy in BPD doesn′t found serious adverse effect to cardio-vascular function as well as coagulation function,and doesn′t increase the risk of intracranial hemorrhage and retinopathy of prematurity.
