Clinical analysis of 33 cases of neonatal group B streptococcal sepsis
10.3760/cma.j.issn.1673-4912.2016.04.008
- VernacularTitle:新生儿B族链球菌败血症33例临床分析
- Author:
Zhiyong LIU
;
Jinglin XU
;
Ruiquan WANG
;
Lianqiang WU
;
Dongmei CHEN
- Publication Type:Journal Article
- Keywords:
Group B Streptococcus;
Sepsis;
Neonate
- From:
Chinese Pediatric Emergency Medicine
2016;23(4):248-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics of neonatal group B streptococcal sepsis (GBS)sepsis in order to provide the guide for early diagnosis and appropriate treatment.Methods A retro-spective review was performed and a total of 33cases of neonatal GBS sepsis were identified in the NICU of Children′s Hospital of Quanzhou from March 2011to October 2014.The perinatal factors,clinical characteris-tics,laboratory finding,treatment and prognosis were analyzed.Results A total of 33cases of neonatal GBS sepsis were identified.The incidence of neonatal GBS sepsis was 2.0‰(33/16448)among all the NICU pa-tients admitted at the same period.All 21cases of early-onset GBS sepsis were term infants,which had 13ca-ses of respiratory distress,11cases of anhelation and 10cases of cyanosis as main initial clinical symptoms. Among 12late-onset cases,8occurred in term infants,10with ardent fever as the main initial clinical symp-toms,6combined with purulent meningitis.All the GBS strains were sensitive to vancomycin,then penicillin combined with meropenem therapy was effective.Of the 33patients,18cured,9discharged with improve-ment,2died,4patients died during hospitalization after being given up because of serious complication,total mortality was 18.2%.Conclusion The clinical manifestations of neonatal GBS sepsis are usually obviously and fatally,and with a high mortality.Antepartum prophylaxis,early diagnosis and timely sensitive antibiotics therapy are vital for reducing the incidence of complications and mortality of neonatal GBS sepsis.
