Altered Regional Homogeneity in Bipolar Depression:A Resting-state Functional Magnetic Resonance Imaging Study

VernacularTitle:双相障碍抑郁相患者静息态脑功能磁共振局部一致性的研究
Author: Xiaowei JIANG ; Qian ZHOU ; Yanqing TANG ; Fei WANG
Publication Type:Journal Article
Keywords: bipolar depression; resting-state; functional magnetic resonance imaging; regional homogeneity
From: Journal of China Medical University 2016;45(4):305-308
CountryChina
Language:Chinese
Abstract: Objective To study the abnormal alteration of regions in bipolar depression patients,so as to investigate its pathophysiologic mecha?nism. Methods Regional homogeneity(ReHo)technology of resting?state functional magnetic resonance imaging were used to compare 24 bipolar depression patients and 28 healthy controls. Results Compared to the healthy controls,the bipolar depression patients exhibited significantly higher ReHo value in the bilateral superior frontal gyrus,the bilateral middle frontal gyrus,the bilateral medial frontal cortex,the bilateral supplementary motor area,the left paracentral lobule and the left precentral gyrus(all P<0.001). Conclusion The abnormal function in the bilateral superior frontal gyrus,the bilateral middle frontal gyrus,the bilateral medial frontal cortex,the bilateral supplementary motor area,the left paracentral lobule and the left precentral gyrus may associate with the mechanism of pathophysiology in bipolar depression.