Correlation between the Glucose Variability and the Disease Severity in Patients with Acute Traumatic Brain Injury
10.12007/j.issn.0258-4646.2016.04.007
- VernacularTitle:急性创伤性颅脑损伤患者围手术期血糖变化与颅脑损伤严重程度的相关性
- Author:
Yijun BAO
;
Shanwei TAO
;
Lizhuo LI
;
Dewei ZHANG
;
Pengfei WANG
;
Xiaolong HUANG
;
Wentai ZHANG
;
Dan ZHAO
;
Yunjie WANG
- Publication Type:Journal Article
- Keywords:
acute isolated traumatic brain injury;
glucose variability;
the duration of hyperglycemia
- From:
Journal of China Medical University
2016;45(4):313-317
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between the glucose variability and the severity of acute isolated traumatic brain injury(TBI). Method According to the inclusion/exclusion criteria,a total of 125 cases of acute isolated TBI admitted in Department of Neurosurgery of China Medical University from July 2012 to June 2015 were included. According to Glasgow coma scale(GSC),the patients were divided into five groups including control(GCS 15),mild(GCS 13?14),moderate(GCS 9?12),severe(GCS 6?8),and extra?severe(GCS 3?5)groups. Blood glucose control(including relief of the stress and the application of insulin)were carried out immediately. The average,standard deviation,and variation co?efficient of blood glucose of all groups were recorded at admission,48 hours and 3?7 days after hospitalization. The clinical records and glycemic in?dex were compared among different groups and during different periods,so as to analyze the relationship of the variability of glucose and the duration of hyperglycemia with the severity of TBI and the effects of glycemic intensive care management. Results The results of Kruskal Wallis test and Mann?Whitney Utest showed that the average,standard deviation,and variation coefficient of glucose in the extra?severe group and the severe group were statistically higher than those in the control group(P<0.05)during the same period. Meanwhile,the average,standard deviation,and variation coefficient of glucose at admission,48 hours and 3?7 days after hospitalization were also different among each group(P<0.05). The duration of hy?perglycemia and conscious disturbance in both the extra?severe group and the severe group were longer than those in the control(P<0.05). The analyses using rank correlation indicated that glucose variability,the level and duration of hyperglycemia were positively correlated with the severity of TBI(r>1). Conclusion The glucose variability in acute isolated TBI patients could be considered as the index of the severity of TBI.
