Effect of Opiod Pretreatments on Etomidate Induced Myoclonus:A Meta-analysis

VernacularTitle:阿片类药物预处理对依托咪酯注射所致肌阵挛影响的meta分析
Author: Peng QIU ; Shuang QIU ; Youjing DONG
Publication Type:Journal Article
Keywords: etomidate; myoclonus; opiod; meta-analysis
From: Journal of China Medical University 2016;45(4):318-323
CountryChina
Language:Chinese
Abstract: Objective To assess the effect of opiod pretreatment on etomidate induced myoclonus. Methods The pertinent literatures were searched by two independent investigators from the following electronic databases:PubMed,Cochrane Library,EMbase,VIP,WanFang Data,and CHKD. Then the meta?analysis was performed by using RevMan 5.2 and STATA 12.0 software. Results A total of 24 RCTs involving 2 396 pa?tients were included for the study. Pretreatment ofμorκ?receptor agonists reduced myoclonus with RR=0.19(95%CI 0.14 to 0.27)and RR=0.22 (95%CI 0.12 to 0.40),respectively. Conclusion Pretreatment of opiods can reduce the incidence of etomidate induced myoclonus.