Role and regulatory mechanism of PRMT5 expression in tumors
10.3969/j.issn.1000-4718.2016.04.028
- VernacularTitle:PRM T5在肿瘤中的作用及其调控机制的研究进展
- Author:
Huantian ZHANG
;
Huadong WANG
;
Zhengang ZHA
- Publication Type:Journal Article
- Keywords:
RMT5;
Tumors
- From:
Chinese Journal of Pathophysiology
2016;32(4):752-758
- CountryChina
- Language:Chinese
-
Abstract:
Protein arginine methyltransferases ( PRMTs) play crucial roles in the methylation of a series pro-tein substrates.PRMT5 is a type Ⅱ methyltransferase that symmetrically methylates arginine residues of histone and non-histone substrates, thereby regulating a variety of cellular processes through epigenetic control of target gene expression or post-translational modification of signaling molecules.Recently, accumulated evidence has suggested that PRMT5 may function as an oncogene.This review is aimed to summarize the oncogenic role of PRMT5 and its regulatory mechanisms in tumors.
