Effects of Dexmedetomidine Combined with Sufentanil in the Treatment of Postoperative Analgesia after Laparoscopic Surgery
10.12007/j.issn.0258-4646.2016.04.011
- VernacularTitle:右美托咪定复合舒芬太尼用于妇科腹腔镜手术患者术后镇痛的效果观察
- Author:
Huanhuan ZHANG
;
Yang LI
;
Xiufei TENG
;
Yanchao YANG
;
Yuxiao WAN
;
Jingjie WAN
;
Junchao ZHU
- Publication Type:Journal Article
- Keywords:
dexmedetomidine;
sufentanil;
postoperative analgesia;
laparoscopic sugery
- From:
Journal of China Medical University
2016;45(4):333-336
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of dexmedetomidine combined with sufentanil in the treatment of self?control intravenous an?algesia after laparoscopic surgery. Methods Sixty patients,who underwent laparoscopic sugery and general anaesthesia,American Society of Anes?thesiologistsⅠtoⅡ,were randomly divided into dexmedetomidine(DS)group and sufentanil(S)group,with thirty cases in each group. Group S received sufentanil 2μg·kg-1 and ramosetron hydrochloride 0.3 mg;group DS received sufentanil 2μg·kg-1,dexmedetomidine 200μg and ramose?tron hydrochloride 0.3 mg. Drugs of both groups were dissolved in saline 100 mL,with a loading dose of 4 mL,background infusion of 2 mL·h-1,con?trolled dose of 0.5 mL·h-1,and the lockout time was 15 min. Visual analog scale(VAS)score,Ramsay sedation scale(RSS)score,sufentanil cu?mulative consumption after surgery at 2 h,4 h,6 h,12 h,24 h were recorded,as well as the adverse reactions such as nausea,the occurrence of vomiting and chills within 24 h after surgery,and the satisfaction of patients with postoperative analgesia. Results Six hours post operation,VAS score of group DS was significantly lower than the group S(P<0.05);2 hours post operation,RSS score of group DS was significantly higher than the group S(P<0.05);the cumulative consumption within 6 hours after sufentanil was significantly lower in group DS than group S(P<0.05). The incidence of nausea,vomiting,chills and other adverse reactions were significantly higher in group S than group DS(P<0.05). Conclusion Compared with the simple application of sufentanil,dexmedetomidine combined with sufentanil for postoperative analgesia achieve better analgesic effect,reducing the amount of sufentanil,while reducing the associated sufentanil adverse reactions,improve patient comfort and satisfaction of post?operative analgesia.
